Psoriasis – Etiology, Pathogenesis and Clinical Features
Psoriasis – Etiology, Pathogenis and Clinical features
Definition: Psoriasis is a common chronic recurrent multifactorial disease characterized by cutaneous inflammation, silvery scales, and parakeratotic immature cells in the stratum corneum due to accelerated epidermopoesis.
Aetiology of Psoriasis
- Sunlight – 10% of the patient
Pathogenesis of Psoriasis
- Accelerated epidermal cell proliferation. Increase cell mitosis in the basal layer of the epidermis
- Rapid cell movement from the basal layer to the stratum corneum layer due to rapid cell turnover. Nucleated Keratinocytes (Epidermal Cell) are present in the stratum corneum.
These nucleated cells are called parakeratotic cells and the condition is called parakeratosis.
Normal cell turnover time is 26-42 days
But in psoriasis turn over time is only 3-4 days.
- Silvery scales are due to air trapping within the cell layers accumulated in the surface of the skin.
- Regular epidermal hyperplasia, Test tube shaped ridges, dilatation of dermal papillae. Removal of scales cause pin point bleeding called Auspitz’s sign.
- Here Munro Micro Abscess is formed which is diagnostic criteria of Psoriais
Fig: Histology Of Munro Microabscess
Munro Micro Abscess composed of degenerated polymorphonuclear leukocytes (PMN’s) in the horny layer (stratum corneum) and are seen in psoriasis and seborrheic dermatitis.
Example of Munro microabscesses in Psoriasis.
- Hyperkeratosis (20-30 white layer; Normally 2-3 layer)
Clinical Features of Psoriasis
- Rounded circumscribed erythromatous patches of various sizes covered by well defined silvery scales
- Usually Lesions are bilateral & symmetrical and involve the external surface. Lesions may be single or few patches.
- Chronic and recurrent disease.
- Nail Involvement
2. Oil drops
Fig: Oil Drop Nail
3. Salmon patches
Fig: Salmon Patches
Fig: Pitting Nail
5. Subungual debris
Fig: Subungual Debris
7. Splinter hemorrhage
Fig: Splinter Hemorrhage
5. Joint Involvement – Psoriatic arthropathy
Fig: Psoriatic arthropathy
6. Auspitz’s Sign – Pin point bleeding on removal of scales
Fig: Auspitz’s Sign
7. Koebner Phenomena (Bed Side Test) – Appearance of typical lesions on the sites of trauma
8. Guttate psoriasis and Flexural psoriasis may be pruritic.
Fig: Erythrodermic Psoriasis
Reference for my Psoriasis article:
1) ANDREWS DISEASES OF THE SKIN CLINICAL DERMATOLOGY