• Skip to main content
  • Skip to secondary menu
  • Skip to primary sidebar
  • Home
  • Notice
  • Result
    • Admission
    • BPSC
    • National University
      • Honours
      • Masters
    • PSC
    • SSC Result
    • HSC Result
  • Free Download Zone
    • Form
    • Medical Books
    • Mobile Corner
    • Freelancing
  • Medicine
    • Infectious Disease
    • Surgery
    • Orthopaedics
      • Saif Orthopaedics
    • Gynaecology
    • Easy Remember
  • Others
    • Life Style
    • Festival
  • Review

Bangladesh Result

All Result in One Place

  • About Me
  • Privacy Policy
  • Terms and Conditions
    • DMCA Policy
  • Contact
    • Ad Service
  • Sitemap
Home » Medicine » Felty's Syndrom

Felty’s Syndrom – What is it? Medical Review

Table of Contents

  • What is Felty’s Syndrom?
  • In Felty’s syndrome—the triad of
    • Felty’s Syndrome Risk factors
    • Felty’s Syndrom Common clinical features
    • Causes of Neutropenia:
  • Bottom Line Of Felty’s Syndrom:

What is Felty’s Syndrom?

Felty’s syndrome is defined by the clinical triad of neutropenia, splenomegaly, and nodular Rheumatoid Arthritis and is seen in less than 1% of patients, although its incidence appears to be declining in the face of more aggressive treatment of the joint disease. It typically occurs in white patients in the late stages of severe Rheumatoid Arthritis. T cell large granular lymphocyte leukemia (T-LGL) may have a similar clinical presentation and often occurs in association with Rheumatoid Arthritis. – Reference  Harrison’s Principles of Internal Medicine: Volumes 1 and 2, 18th Edition

In Felty’s syndrome—the triad of

Felty’s Syndrom
Felty’s Syndrom

Rheumatoid Arthritis Splenomegaly and Neutropenia Spleen produced antibodies can shorten neutrophil life span, while LGLs can attack marrow neutrophil precursors. Splenectomy may increase the neutrophil count in Felty’s syndrome and lower serum neutrophil binding IgG. Some Felty’s syndrome patients also have neutropenia associated with an increased number of LGLs. Splenomegaly with peripheral trapping and destruction of neutrophils is also seen in lysosomal storage diseases and in portal hypertension. – Reference  Harrison’s Principles of Internal Medicine: Volumes 1 and 2, 18th Edition

Felty’s Syndrome Risk factors

Age of onset 50-70 yrs Female > male Caucasians > blacks Long-standing Rheumatoid Arthritis Deforming but inactive disease Seropositive for Rheumatoid Fever – Reference Davidson’s Principles and Practice of Medicine

Felty’s Syndrom Common clinical features

• Splenomegaly • Lymphadenopathy • Weight loss • Skin pigmentation • Keratoconjunctivitis sicca • Vasculitis, leg ulcers • Recurrent infections • Nodules – Reference Davidson’s Principles and Practice of Medicine  So why you need to know the disease which is rare? Because you can find it in Neutropenia

Causes of Neutropenia:

Bone marrow disorders

Aplastic anemia
Pure white cell aplasia
Congenital
Cyclic neutropenia
Drugs: sulfonamides, chlorpromazine, procainamide, penicillin, cephalosporins, cimetidine, methimazole, phenytoin, chlorpropamide, antiretroviral medications
Benign chronic
Large granular lymphocytic leukemia
Peripheral disorders
Hypersplenism
Sepsis
Immune
Felty’s syndrome
HIV infection

Reference – CURRENT Medical Diagnosis and Treatment 2012, Fifty-First Edition (LANGE CURRENT Series)

Bottom Line Of Felty’s Syndrom:

A small subset of patients with rheumatoid arthritis have Felty syndrome, the occurrence of splenomegaly and neutropenia, usually in the setting of severe, destructive arthritis. Felty syndrome must be distinguished from the large granular lymphocyte syndrome, with which it shares many features. – Reference Kumar and Clark’s Clinical Medicine

Reader Interactions

Leave a Reply Cancel reply

Your email address will not be published. Required fields are marked *

This site uses Akismet to reduce spam. Learn how your comment data is processed.

Primary Sidebar

Categories

  • Admission (7)
    • Medical (1)
  • Easy Remember (4)
  • Festival (8)
    • Eid (2)
  • Form (4)
  • Free Download Zone (33)
    • Medical Books (1)
    • Tips and Tricks (10)
  • Freelancing (28)
    • WordPress (3)
  • Gynaecology (16)
  • Infectious Disease (1)
  • Job (10)
  • Life Style (25)
  • Medicine (17)
  • Mobile Corner (12)
  • Notice (5)
  • Orthopaedics (3)
  • Others (15)
  • Question Solve (4)
  • Result (73)
    • Admission (9)
    • BPSC (9)
    • HSC Result (9)
    • JSC (4)
    • National University (11)
      • Degree (2)
      • Honours (4)
      • Masters (3)
    • NTRCA (2)
    • Prize Bond (2)
    • PSC (5)
    • Scholarship (1)
    • SSC Result (13)
  • Review (26)
  • Routine (8)
  • Saif Orthopaedics (14)
  • SEO (8)
  • Sports (4)
  • Surgery (4)
  • Uncategorized (3)

Recent Posts

  • Betting Site in Bangladesh – Top Sites for Satta Online
  • How to Stay Productive as a Student
  • [How To] Fix the WordPress Not Sending Emails Issue
  • Overview of the Main Benefits of Sentiment Analysis
  • 3 Resonating Content Optimization Strategies

Copyright © 2023 | Hosting Partner Boss Host BD

Go to mobile version